By Leslie J. DeGroot (auth.), Barry B. Bercu, Dorothy I. Shulman (eds.)
Perinatal difficulties in thyroid gland body structure are universal yet complex and current a diagnostic predicament for the first clinician. In December 1990, a world staff of easy and medical investigators accumulated in Longboat Key, Florida to deal with those matters. The individuals integrated internists, obstetricians, pedia tricians, neurologists, pathologists and simple scientists in mobile metabolism, endocrine body structure, and molecular biology. The shows contained inside of this ebook collect their most present and important examine with regards to the sector of perinatal thyroidology. This ebook is predicated at the dynamic and fruitful alternate of the contributors on the symposium. we're indebted to those contributors whose worthwhile insights and efforts are contained inside this article. Barry B. Bercu Dorothy I. Shulman vii CONTENTS consultation I Mechanism of Thyroid Hormone motion 1 Leslie J. DeGroot Thyroid method Ontogeny within the Sheep: A version for Precocial Mammalian Species • . . • • eleven Delbert A. Fisher Pathologic experiences of Fetal Thyroid 27 improvement • • • • • • • Douglas R. Shanklin Thyroid Hormone regulate of mind and Motor improvement: Molecular, Neuroanatomical, forty seven and Behavioral stories • • • • • • • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, and M. B. Palnitkar The Thyroidectomized Pregnant Rat: An Animal version to review Fetal results of Maternal Hypothyroidism 107 Susan P. Porterfield and Chester E.
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Additional info for Advances in Perinatal Thyroidology
Breall JA, Rudolph AM, Heymann MA. Role of thyroid hormone in postnatal circulating and metabolic adjustments. J Clin Invest 743:1418-1424 (1984). Padbury JF, Klein AH, Polk DH, Lam RW, Hobel CJ, Fisher DA. The effect of thyroid status on lung and heart beta adrenergic receptors in fetal and newborn sheep. Devel Pharmacol Therapeut 9:44-53 (1986). Cheromcha DP, Callegari CC, Reviczky A, Polk DH, Fisher DA. Ontogenesis of thyroid hormone receptor and post-receptor effects in fetal ovine liver. Clin Res 35:232A (1987) • PATHOLOGIC STUDIES OF FETAL THYROID DEVELOPMENT Douglas R.
TI THYROID CONTROL OF BRAIN AND MOTOR DEVELOPMENT 55 fold reductions in serum thyroxine(T4)(Beamer et aI, 1981, Stein et aI, 1989b)(FIGURE 3, Panel A), a 16 fold dimunition in triiodothyronine(TI)(Stein et aI, 1989b) a toO fold elevation in TSH-like activity(Stein et aI, 1989b)(FJGURE 3, PANEL B), increased numbers of pituitary thyroid stimulating hormone(TSH) granules(Noguchi et aI, 1986), and reduced hypothalamic TRH(Noguchi et aI, 1986), when compared to euthyroid lll1/ + mice and progenitor strain BALB/cBY + / + mice.
Wollman: Mechanisms for abnormally slow release of some thyroid radioiodine; an autoradiographic study. R. W. A. Brent: Increased need for thyroxine during pregnancy in women with primary hypothyroidism. Ked. : Prenatal and early postnatal ontogenesis of the human motor cortex: a golgi study. I. The sequential development of the cortical layers. Brain Res. : Postmortem pulmonary edema; differential susceptibility in newborn and adult rabbits. Pathol. H. Wollman: Fine structure of a fifth type of epithelial cell in the thyroid gland of the C3H mouse.