By Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
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Extra info for An Introduction to Genetic Analysis
In Chapter 2, you’ll learn how to calculate such probabilities. With this hint from the family history, the UDP team now knew where to look in the genome for the mutant gene. They needed to look for a segment on one of the chromosomes for which the copy that Benge inherited from her mother is identical to the copy she inherited from her father. Moreover, each of Benge’s siblings must also have two copies of this segment identical to Benge’s. Such regions are very rare in people unless their parents are related, as in the case of Benge since her parents are third cousins.
07 the genes Figure #123 necessary to metabolize the sugar lactose in the bacterium Escherichia coli, they demonstrated that genes have regulatory elements that regulate 04/03/14 Dragonfly Media Group gene expression—that is, whether a gene is turned on or off (Figure 1-9). The regulatory elements are specific DNA sequences to which a regulatory protein binds and acts as either an activator or repressor of the expression of the gene. In Chapter 11, you will explore the logic behind the experiments of Jacob and Monod with E.
Can Mendelian genes explain the inheritance of continuously variable traits like human height? While 3 : 1 segregation ratios could be directly observed for simple traits like flower color, many traits show a continuous range of values in secondgeneration hybrids without simple ratios like 3 : 1. In 1918, Ronald Fisher, the British statistician and geneticist, resolved how Mendelian genes explained the inheritance of continuously variable traits like height in people (Figure 1-6). Fisher’s core idea F I G U R E 1- 5 William Bateson, the British zoologist and evolutionist who introduced the term genetics for the study of inheritance and promoted Mendel’s work.