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Circ Res 1979;44:430–436. 16. Challis JRG, Patrick JE. The production of prostaglandins and thromboxanes in the feto-placental unit and their effects on the developing fetus. Semin Perinatol 1980;4:23–33. 17. Mitchell MD, Flint AP, Bibby J, et al. Plasma concentrations of prostaglandins during late human pregnancy: influence of normal and preterm labor. J Clin Endocrinol Metab 1978;46:947–951. R. Martin 18. Novy MJ, Piasecki G, Jackson BT. Effect of prostaglandins E2 and F2 alpha on umbilical blood flow and fetal hemodynamics.

In current ultrasonography, multiple transducers generate many sound waves simultaneously or in sequence to create real-time images to detect movement. This method allows monitoring not only of static fetal defects but also of fetal movements, breathing, or cardiac motions, and even blood vessel pulsation deficits. 7 Amniocentesis Amniocentesis is the invasive prenatal diagnostic test most commonly used for genetic disease. The technique is considered to be relatively simple and is performed transabdominally with the use of ultrasonography.

Philadelphia: Saunders, 1998:671–676. 61. Cohn HE, Piasecki GJ, Jackson BT. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 1974;129: 817–824. 62. Parer JT. The effect of acute maternal hypoxia on fetal oxygenation and the umbilical circulation in the sheep. Eur J Obstet Gynecol Reprod Biol 1980;10:125–136. 63. Mann LI. Effects in sheep of hypoxia on levels of lactate, pyruvate and glucose in blood of mothers and fetus. Pediatr Res 1970;4:46–54. 64. Jones MD, Sheldon RE, Peeters LL, et al.

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